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Cystamine dihydrochloride
CAS No. 56-17-7
Cystamine dihydrochloride( —— )
Catalog No. M24550 CAS No. 56-17-7
Cystamine dihydrochloride is a radiation-protective agent. It also protects against carbon tetrachloride liver damage.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCystamine dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionCystamine dihydrochloride is a radiation-protective agent. It also protects against carbon tetrachloride liver damage.
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DescriptionCystamine dihydrochloride is a radiation-protective agent. It also protects against carbon tetrachloride liver damage.
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In VitroCystamine (dihydrochloride) has inhibition activity for caspase-3 with an IC50 value of 23.6 μM.Cystamine (0-500 μM; 0-16 h) inhibits recombinant active caspase-3 in a concentration-dependent manner. Cystamine (250 μM; 10 h) robustly increases the levels of glutathione. Western Blot Analysis Cell Line:Human neuroblastoma SH-SY5Y cells Concentration:250, 500 μM Incubation Time:0-16 h Result:Inhibited the MG132-mediated activation of caspase-3.Inhibited the H2O2-mediated activation of caspase-3.Inhibited caspase-3 activity in a tTG-independent manner.
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In VivoCystamine (dihydrochloride) (oral, i.p.; 112, 225 mg/kg) reduces Tgase activity and GGEL levels, lessens the behavioral and neuropathological severity, and extends survival in R6/2 transgenic HD mice. Animal Model:R6/2 transgenic HD miceDosage:112, 225 mg/kg Administration:Intraperitoneal or oral, daily Result:Significantly extended survival, improved body weight and motor performance, delayed the neuropathological sequela and significantly altered the levels of Tgase activity and N(Sigma)-(gamma-L-glutamyl)-L-lysine (GGEL) levels.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number56-17-7
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Formula Weight225.19
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Molecular FormulaC4H14Cl2N2S2
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Purity>98% (HPLC)
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SolubilityDMSO:Soluble
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SMILESC(CSSCCN)N.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Roncoroni L, Elli L, Braidotti P, et al. Transglutaminase 2 Mediates the Cytotoxicity of Resveratrol in a Human Cholangiocarcinoma and Gallbladder Cancer Cell Lines. Nutr Cancer. 2018 May 14:1-9.
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